Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals

Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals

Transepithelial fluid and salt re-absorption in epithelial tissues play an important role in fluid and salt homeostasis. In absorptive epithelium, fluid and salt flux is controlled by machinery mainly composed of epithelial sodium channels (ENaC), cystic fibrosis transmembrane conductance regulator (CFTR), Na⁺/H⁺ exchanger (NHE), aquaporin, and sodium potassium adenosine triphosphatase (Na⁺/K⁺-...

Aquaporin water channels in transepithelial fluid transport.

Aquaporins (AQPs) are membrane water channels that are involved in a diverse set of functions in mammalian physiology including epithelial fluid transport, brain water balance, cell migration, cell proliferation, neuroexcitation, fat metabolism, epidermal hydration, and others. Phenotype analysis of knockout mice has demonstrated an important role for AQPs in transepithelial fluid transport in ...

Respiration and Salt Absorption by Excised Barley Roots.

Functional TRPV6 channels are crucial for transepithelial Ca absorption

Titia E. Woudenberg-Vrenken, Anke L. Lameris,* Petra Weißgerber,* Jenny Olausson, Veit Flockerzi, René J. M. Bindels, Marc Freichel, and Joost G. J. Hoenderop Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Germany; and Pharmakologisches Institut, Uni...

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.

TRPV6 is considered the primary protein responsible for transcellular Ca2+ absorption. In vitro studies demonstrate that a negatively charged amino acid (D) within the putative pore region of mouse TRPV6 (position 541) is critical for Ca2+ permeation of the channel. To elucidate the role of TRPV6 in transepithelial Ca2+ transport in vivo, we functionally analyzed a TRPV6D541A/D541A knockin mous...